Correction: Curcumin inhibits cellular condensation and alters microfilament organization during chondrogenic differentiation of limb bud mesenchymal cells
نویسندگان
چکیده
منابع مشابه
IL-17 Inhibits Chondrogenic Differentiation of Human Mesenchymal Stem Cells
OBJECTIVE Mesenchymal stem cells (MSCs) can differentiate into cells of mesenchymal lineages, such as osteoblasts and chondrocytes. Here we investigated the effects of IL-17, a key cytokine in chronic inflammation, on chondrogenic differentiation of human MSCs. METHODS Human bone marrow MSCs were pellet cultured in chondrogenic induction medium containing TGF-β3. Chondrogenic differentiation ...
متن کاملCell contact and surface coat alterations of limb-bud mesenchymal cells during differentiation.
Measurements of the cell perimeter, cell-cell contact number and length and of the thickness of the surface coat were performed in limb buds of mouse embryos during the process of cell condensation of the chondrogenic cell mass. This study starts with measurements of 'non-limb' mesenchyme of day-9 embryos and ends with the young cartilage of day 13. It is shown that until day 12 all cells in th...
متن کاملEffects of BIO on proliferation and chondrogenic differentiation of mouse marrow-derived mesenchymal stem cells
In vitro expansion of mesenchymal stem cell (MSCs) into large number is necessary for their application in cell-based treatment of articular cartilage defects. On the other hand, some studies have indicated that BIO (6-Bromoindirubin-3-Oxime) possesses mitogenic effects on cell culture. The objective of the present study was to examine the effect of BIO on in vitro expansion and chondrogenic di...
متن کاملMagneto-mechanical Stimulation of Bone Marrow Mesenchymal Stromal Cells for Chondrogenic Differentiation Studies
Mechanical interaction of cells and their surroundings are prominent in mechanically active tissues such as cartilage. Chondrocytes regulate their growth, matrix synthesis, metabolism, and differentiation in response to mechanical loadings. Cells sense and respond to applied physical forces through mechanosensors such as integrin receptors. Herein, we examine the role of mechanical stimulation ...
متن کاملThe Oncogene LRF Stimulates Proliferation of Mesenchymal Stem Cells and Inhibits Their Chondrogenic Differentiation
OBJECTIVE The oncogene leukemia/lymphoma-related factor (LRF) enhances chondrosarcoma proliferation and malignancy. This study aimed to investigate the roles of LRF in chondrogenic differentiation of primary human bone marrow-derived mesenchymal stem cells (BMSCs). DESIGN LRF was overexpressed in BMSC by lentiviral transduction. Chondrogenic differentiation of BMSC was induced by high-density...
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ژورنال
عنوان ژورنال: Experimental & Molecular Medicine
سال: 2020
ISSN: 1226-3613,2092-6413
DOI: 10.1038/s12276-019-0365-5